Post Limit ( ) You could ask me things or w/e that might be cool

whats-the-big-deal:

menthuthuyoupi:

what is James Franco doing

hes doing us all a favor


July 29 ( 34778 ) via /

dulect:

if your teenage years are meant for experimenting with relationships i’m fucked

dutchster:

do parents feel offended when their kids call themselves ugly like hey those are my genetics you’re talking about

calumamnesias:

HOW YOUNG DO MICHAEL AND ASHTON LOOK


July 29 ( 3279 ) via / source

lizziemcganja:

friend: i’m getting mcdonalds you want anything?

me: i don’t have money

friend: it’s all good, i’ll pay

me:

image

image

vegan-vulcan:

I’m really really really really really glad that a whole bunch of dudes accidentally gave us really detailed instruction manuals for how to repel misogynists


July 29 ( 14107 ) via / source

dailytylerhoechlin:

Tyler Hoechlin for August Man Malaysia August 2014 issue.(x)


July 29 ( 12178 ) via / source

seselapod:

I THINK MY FAVORITE THING IS WHEN PEOPLE GET REALLY MAD OR FRUSTRATED OR SAD IN THEIR TAGS AND YELL ABOUT HOW UPSET THEY ARE IN ALL CAPS AND THEYRE ONE OF THOSE PEOPLE THAT TAG REGULARLY SO IT’S JUST ALL THIS SCREAMING AND THEN LIKE fandom title in lowercase

jmarietee:

lilith-not-eve:

Marrying young is not the end of my freedom. It means I want to travel and see the world, but with her by my side. It means I still like drinking in bars and dancing in clubs, but stumbling home with her at 2am and eating pizza in our underwear. It means I know that I want to kiss those lips every morning, and every night before bed. If you see marriage as the end of your ‘freedom’, you’re doing it wrong.

Well this was just beautiful

neurosciencestuff:

Memory relies on astrocytes, the brain’s lesser known cells

When you’re expecting something—like the meal you’ve ordered at a restaurant—or when something captures your interest, unique electrical rhythms sweep through your brain.

These waves are called gamma oscillations and they reflect a symphony of cells—both excitatory and inhibitory—playing together in an orchestrated way. Though their role has been debated, gamma waves have been associated with higher-level brain function, and disturbances in the patterns have been tied to schizophrenia, Alzheimer’s disease, autism, epilepsy and other disorders.

Now, new research from the Salk Institute shows that little known supportive cells in the brain known as astrocytes may in fact be major players that control these waves.

In a study published July 28 in the Proceedings of the National Academy of Sciences, Salk researchers report a new, unexpected strategy to turn down gamma oscillations, by disabling not neurons but astrocytes—cells type traditionally thought to provide more of a support role in the brain. In the process, the team showed that astrocytes, and the gamma oscillations they help shape, are critical for some forms of memory.

"This is what could be called a smoking gun," says co-author Terrence Sejnowski, head of the Computational Neurobiology Laboratory at the Salk Institute for Biological Sciences and a Howard Hughes Medical Institute investigator. "There are hundreds of papers linking gamma oscillations with attention and memory, but they are all correlational. This is the first time we have been able to do a causal experiment, where we selectively block gamma oscillations and show that it has a highly specific impact on how the brain interacts with the world."

A collaboration among the labs of Salk professors Sejnowski, Inder Verma and Stephen Heinemann found that activity in the form of calcium signaling in astrocytes immediately preceded gamma oscillations in the brains of mice. This suggested that astrocytes, which use many of the same chemical signals as neurons, could be influencing these oscillations.

To test their theory, the group used a virus carrying tetanus toxin to disable the release of chemicals released selectively from astrocytes, effectively eliminating the cells’ ability to communicate with neighboring cells. Neurons were unaffected by the toxin.

After adding a chemical to trigger gamma waves in the animals’ brains, the researchers found that brain tissue with disabled astrocytes produced shorter gamma waves than in tissue containing healthy cells. And after adding three genes that would allow the researchers to selectively turn on and off the tetanus toxin in astrocytes at will, they found that gamma waves were dampened in mice whose astrocytes were blocked from signaling. Turning off the toxin reversed this effect.

The mice with the modified astrocytes seemed perfectly healthy. But after several cognitive tests, the researchers found that they failed in one major area: novel object recognition. A healthy mouse spent more time with a new item placed in its environment than it did with familiar items, as expected.

In contrast, the group’s new mutant mouse treated all objects the same. “That turned out to be a spectacular result in the sense that novel object recognition memory was not just impaired, it was gone—as if we were deleting this one form of memory, leaving others intact,” Sejnowski says.

The results were surprising, in part because astrocytes operate on a seconds- or longer timescale whereas neurons signal far faster, on the millisecond scale. Because of that slower speed, no one suspected astrocytes were involved in the high-speed brain activity needed to make quick decisions.

"What I thought quite unique was the idea that astrocytes, traditionally considered only guardians and supporters of neurons and other cells, are also involved in the processing of information and in other cognitive behavior," says Verma, a professor in the Laboratory of Genetics and American Cancer Society Professor.

It’s not that astrocytes are quick—they’re still slower than neurons. But the new evidence suggests that astrocytes are actively supplying the right environment for gamma waves to occur, which in turn makes the brain more likely to learn and change the strength of its neuronal connections.

Sejnowski says that the behavioral result is just the tip of the iceberg. “The recognition system is hugely important,” he says, adding that it includes recognizing other people, places, facts and things that happened in the past. With this new discovery, scientists can begin to better understand the role of gamma waves in recognition memory, he adds.


July 29 ( 313 ) via /

wickedisgood:

The eleventh, and final, new poster for The Maze Runner [x]


July 29 ( 135 ) via /

geeky-sova:

Gift pic commissioned by Mav to go with a very sweet fic called You remind me of a reason by Pollitt ♥ 


July 29 ( 1536 ) via / source

kirayukimura:

lydia flippin the bird :——)


July 29 ( 1573 ) via / source